› 5owa

X-ray diffraction
1.95Å resolution

Crystal structure of the human BRPF1 bromodomain in complex with BZ054

Released:
DOI: 10.2210/pdb5owa/pdb
PDB entry 5owa coloured by chain, front view.
PDB entry 5owa coloured by chain, side view.
PDB entry 5owa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Zhu J, Zhou C, Caflisch A
Eur J Med Chem 155 337-352 (2018)
PMID: 29902720

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157220 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peregrin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 116 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55201 (Residues: 626-740; Coverage: 10%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand B0H 3 x B0H
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 34.889Å b: 92.299Å c: 81.217Å
α: 90° β: 101.22° γ: 90°
R-values:
R R work R free
0.222 0.219 0.268
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment.
Li et al. (2021)
3 more