› 5owr

X-ray diffraction
2.3Å resolution

Human STK10 bound to dasatinib

Released:
DOI: 10.2210/pdb5owr/pdb
PDB entry 5owr coloured by chain, front view.
PDB entry 5owr coloured by chain, side view.
PDB entry 5owr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Szklarz M, Muniz JRC, Vollmar M, von Delft F, Bountra C, Knapp S, Edwards AM, Arrowsmith C, Elkins JM

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-131759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 10 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94804 (Residues: 18-317; Coverage: 31%)
Gene names: LOK, STK10
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 1N1 1 x 1N1
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: I222
Unit cell:
a: 49.74Å b: 111.72Å c: 133.15Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.254
Expression system: Escherichia coli BL21(DE3)

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