› 5oym

X-ray diffraction
2.05Å resolution

HIV Integrase Binding Domain of Lens Epithelium-Derived Growth Factor

Released:
DOI: 10.2210/pdb5oym/pdb
PDB entry 5oym coloured by chain, front view.
PDB entry 5oym coloured by chain, side view.
PDB entry 5oym coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor.
Hannon C, Cruz-Migoni A, Platonova O, Owen RL, Nettleship JE, Miller A, Carr SB, Harris G, Rabbitts TH, Phillips SEV
Acta Crystallogr F Struct Biol Commun 74 143-149 (2018)
PMID: 29497017

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130995 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PC4 and SFRS1-interacting protein Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 111 amino acids
Theoretical weight: 11.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75475 (Residues: 345-431; Coverage: 16%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Sequence domains: Lens epithelium-derived growth factor (LEDGF)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 71.181Å b: 54.814Å c: 117.996Å
α: 90° β: 91.23° γ: 90°
R-values:
R R work R free
0.185 0.182 0.236
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions.
Ortiz-Hernandez et al. (2020)

2 mentions without citation

New targets for HIV drug discovery.
Puhl et al. (2019)
1 more