› 5pab

X-ray diffraction
1.99Å resolution

Crystal Structure of Factor VIIa in complex with 1-[[3-[2-hydroxy-3-(1H-pyrrolo[3,2-c]pyridin-2-yl)phenyl]phenyl]methyl]-3-phenylurea

Released:
DOI: 10.2210/pdb5pab/pdb
PDB entry 5pab coloured by chain, front view.
PDB entry 5pab coloured by chain, side view.
PDB entry 5pab coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Stihle M, Mayweg A, Roever S, Rudolph MG

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140351 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Factor VII heavy chain Chain: H
Molecule details ›
Chain: H
Length: 254 amino acids
Theoretical weight: 28.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08709 (Residues: 213-466; Coverage: 57%)
Gene name: F7
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor VII light chain Chain: L
Molecule details ›
Chain: L
Length: 64 amino acids
Theoretical weight: 6.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08709 (Residues: 149-212; Coverage: 14%)
Gene name: F7
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin

Ligands and Environments

5 bound ligands:
Ligand 7XD 1 x 7XD
Ligand CL 3 x CL
Ligand GOL 4 x GOL
Ligand CA 1 x CA
Ligand SO4 2 x SO4
1 modified residue:
Ligand MHO 1 x MHO

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P41212
Unit cell:
a: 95.217Å b: 95.217Å c: 116.197Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.22
Expression system: Escherichia coli

Quick links