› 5svx

X-ray diffraction
1.56Å resolution

MORC3 CW in complex with histone H3K4me3

Released:
DOI: 10.2210/pdb5svx/pdb
PDB entry 5svx coloured by chain, front view.
PDB entry 5svx coloured by chain, side view.
PDB entry 5svx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Andrews FH, Tong Q, Sullivan KD, Cornett EM, Zhang Y, Ali M, Ahn J, Pandey A, Guo AH, Strahl BD, Costello JC, Espinosa JM, Rothbart SB, Kutateladze TG
Cell Rep 16 3195-3207 (2016)
PMID: 27653685

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159405 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
MORC family CW-type zinc finger protein 3 Chain: A
Molecule details ›
Chain: A
Length: 49 amino acids
Theoretical weight: 5.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14149 (Residues: 407-454; Coverage: 5%)
Gene names: KIAA0136, MORC3, NXP2, ZCWCC3
Sequence domains: CW-type Zinc Finger
Structure domains: Herpes Virus-1
Histone H3.1 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-12; Coverage: 8%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
1 modified residue:
Ligand M3L 1 x M3L

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21212
Unit cell:
a: 31.25Å b: 68.55Å c: 26.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 0.143 0.178
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

MORC Proteins: Novel Players in Plant and Animal Health.
Koch et al. (2017)
4 more

3 mentions without citation

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Andrews et al. (2016)
2 more