› 5t5x

X-ray diffraction
1.84Å resolution

High resolution structure of mouse Cryptochrome 1

Released:
DOI: 10.2210/pdb5t5x/pdb
PDB entry 5t5x coloured by chain, front view.
PDB entry 5t5x coloured by chain, side view.
PDB entry 5t5x coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.
Michael AK, Fribourgh JL, Chelliah Y, Sandate CR, Hura GL, Schneidman-Duhovny D, Tripathi SM, Takahashi JS, Partch CL
Proc Natl Acad Sci U S A 114 1560-1565 (2017)
PMID: 28143926

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161322 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cryptochrome-1 Chain: A
Molecule details ›
Chain: A
Length: 491 amino acids
Theoretical weight: 56.59 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P97784 (Residues: 1-491; Coverage: 81%)
Gene name: Cry1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P1
Unit cell:
a: 43.63Å b: 51.035Å c: 54.175Å
α: 71.62° β: 84.12° γ: 88.89°
R-values:
R R work R free
0.171 0.168 0.232
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Circadian clock genes and the transcriptional architecture of the clock mechanism.
Cox et al. (2019)
13 more

10 mentions without citation

Periodicity, repression, and the molecular architecture of the mammalian circadian clock.
Rosensweig et al. (2020)
9 more