› 5tab

X-ray diffraction
1.25Å resolution

Crystal Structure of the PHD Finger of PHF20

Released:
DOI: 10.2210/pdb5tab/pdb
PDB entry 5tab coloured by chain, front view.
PDB entry 5tab coloured by chain, side view.
PDB entry 5tab coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Klein BJ, Wang X, Cui G, Yuan C, Botuyan MV, Lin K, Lu Y, Wang X, Zhao Y, Bruns CJ, Mer G, Shi X, Kutateladze TG
Cell Rep 17 1158-1170 (2016)
PMID: 27760318

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PHD finger protein 20 Chain: A
Molecule details ›
Chain: A
Length: 53 amino acids
Theoretical weight: 6.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BVI0 (Residues: 651-698; Coverage: 5%)
Gene names: C20orf104, GLEA2, HCA58, NZF, PHF20, TZP
Sequence domains: PhD finger domain
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P61
Unit cell:
a: 46.739Å b: 46.739Å c: 50.928Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.121 0.118 0.144
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

The language of chromatin modification in human cancers.
Zhao et al. (2021)
5 more

3 mentions without citation

PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Klein et al. (2016)
2 more