› 5tbp

X-ray diffraction
2.6Å resolution

Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003

Released:
DOI: 10.2210/pdb5tbp/pdb
PDB entry 5tbp coloured by chain, front view.
PDB entry 5tbp coloured by chain, side view.
PDB entry 5tbp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα.
Chen L, Aleshin AE, Alitongbieke G, Zhou Y, Zhang X, Ye X, Hu M, Ren G, Chen Z, Ma Y, Zhang D, Liu S, Gao W, Cai L, Wu L, Zeng Z, Jiang F, Liu J, Zhou H, Cadwell G, Liddington RC, Su Y, Zhang XK
Nat Commun 8 16066 (2017)
PMID: 28714476

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148719 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 244 amino acids
Theoretical weight: 27.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

4 bound ligands:
Ligand 7A4 6 x 7A4
Ligand ACT 7 x ACT
Ligand DMS 1 x DMS
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: P21
Unit cell:
a: 46.64Å b: 99.38Å c: 109.86Å
α: 90° β: 99.15° γ: 90°
R-values:
R R work R free
0.198 0.196 0.242
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Overview of the structure-based non-genomic effects of the nuclear receptor RXRα.
Chen et al. (2018)
3 more

2 mentions without citation

Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα.
Chen et al. (2017)
1 more