› 5te0

X-ray diffraction
1.9Å resolution

Crystal Structure of Adaptor Protein 2 Associated Kinase (AAK1) in complex with BIBF 1120

Released:
DOI: 10.2210/pdb5te0/pdb
PDB entry 5te0 coloured by chain, front view.
PDB entry 5te0 coloured by chain, side view.
PDB entry 5te0 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Counago RM, Elkins JM, Bountra C, Arruda P, Edwards AM, Gileadi O, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173717 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AP2-associated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 347 amino acids
Theoretical weight: 39.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2M2I8 (Residues: 27-365; Coverage: 35%)
Gene names: AAK1, KIAA1048
Sequence domains: Protein kinase domain
Structure domains: Transferase(Phosphotransferase) domain 1

Ligands and Environments

3 bound ligands:
Ligand XIN 1 x XIN
Ligand PEG 1 x PEG
Ligand GOL 8 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: I222
Unit cell:
a: 70.465Å b: 119.474Å c: 125.035Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.199
Expression system: Escherichia coli

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