› 5tfp

X-ray diffraction
2Å resolution

Crystal Structure of the SETDB2 Amino Terminal Domain

Released:
DOI: 10.2210/pdb5tfp/pdb
PDB entry 5tfp coloured by chain, front view.
PDB entry 5tfp coloured by chain, side view.
PDB entry 5tfp coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Khorasanizadeh S, Kim Y

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-N(6),N(6)-dimethyl-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(9)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188766 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase SETDB2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 64 amino acids
Theoretical weight: 7.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96T68 (Residues: 1-64; Coverage: 9%)
Gene names: C13orf4, CLLD8, KMT1F, SETDB2

Ligands and Environments

2 bound ligands:
Ligand GOL 9 x GOL
Ligand TLA 1 x TLA
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6122
Unit cell:
a: 69.474Å b: 69.474Å c: 120.06Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.163 0.162 0.181
Expression system: Escherichia coli

Quick links