› 5tgz

X-ray diffraction
2.8Å resolution

Crystal Structure of the Human Cannabinoid Receptor CB1

Released:
DOI: 10.2210/pdb5tgz/pdb
PDB entry 5tgz coloured by chain, front view.
PDB entry 5tgz coloured by chain, side view.
PDB entry 5tgz coloured by chain, top view.
Source organisms:
Primary publication:
Crystal Structure of the Human Cannabinoid Receptor CB1.
Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, Kufareva I, Wu B, Zhao Q, Hanson MA, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ
Cell 167 750-762.e14 (2016)
PMID: 27768894

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132392 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cannabinoid receptor 1; Flavodoxin Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 50.34 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P21554 (Residues: 99-306, 332-414; Coverage: 62%)
  • Canonical: P00323 (Residues: 2-148; Coverage: 99%)
Gene names: CNR, CNR1, DVU_2680
Sequence domains:
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand ZDG 1 x ZDG
Ligand FMN 1 x FMN
Ligand OLC 1 x OLC
Ligand OLA 3 x OLA
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 116.56Å b: 52.63Å c: 143.63Å
α: 90° β: 111.14° γ: 90°
R-values:
R R work R free
0.208 0.206 0.238
Expression system: Homo sapiens

Quick links

Citations

88 review citations

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Higashi et al. (2017)
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74 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
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