› 5tkj

X-ray diffraction
2.12Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230790 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
vFP1.01 chimeric mouse antibody heavy chain Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 221 amino acids
Theoretical weight: 23.93 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
vFP1.01 chimeric mouse antibody light chain Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 219 amino acids
Theoretical weight: 24.13 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Transmembrane protein gp41 Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 8 amino acids
Theoretical weight: 733 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 512-519; Coverage: 1%)
Gene name: env

Ligands and Environments

1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 76.159Å b: 120.182Å c: 226.182Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.241
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

40 review citations

Recent progress in broadly neutralizing antibodies to HIV.
Sok et al. (2018)
39 more

1 mention without citation

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Xu et al. (2018)