› 5tqx

Electron Microscopy
5.4Å resolution

CryoEM reconstruction of human IKK1, intermediate conformation 2

Released:
DOI: 10.2210/pdb5tqx/pdb
PDB entry 5tqx coloured by chain, front view.
PDB entry 5tqx coloured by chain, side view.
PDB entry 5tqx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for the Activation of IKK1/α.
Polley S, Passos DO, Huang DB, Mulero MC, Mazumder A, Biswas T, Verma IM, Lyumkis D, Ghosh G
Cell Rep 17 1907-1914 (2016)
PMID: 27851956
Related structures: EMD-8437

Function and Biology Details

Reaction catalysed: 
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127294 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inhibitor of nuclear factor kappa-B kinase subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 655 amino acids
Theoretical weight: 75.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15111 (Residues: 10-660; Coverage: 87%)
Gene names: CHUK, IKKA, TCF16
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.4Å
Relevant EMDB volumes: EMD-8437
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors.
Prescott et al. (2018)
4 more

3 mentions without citation

Structural Basis for the Activation of IKK1/α.
Polley et al. (2016)
2 more