› 5ttr

X-ray diffraction
2.7Å resolution

LEU 55 PRO TRANSTHYRETIN CRYSTAL STRUCTURE

Released:
DOI: 10.2210/pdb5ttr/pdb
PDB entry 5ttr coloured by chain, front view.
PDB entry 5ttr coloured by chain, side view.
PDB entry 5ttr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of amyloidogenic Leu55 --> Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils.
Sebastião MP, Saraiva MJ, Damas AM
J Biol Chem 273 24715-22 (1998)
PMID: 9733771

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 127 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: C2
Unit cell:
a: 149.99Å b: 78.74Å c: 98.95Å
α: 90° β: 100.5° γ: 90°
R-values:
R R work R free
0.199 0.199 not available
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Transthyretin mutations in hyperthyroxinemia and amyloid diseases.
Saraiva MJ. (2001)
9 more

5 mentions without citation

Differential proteome profiling using iTRAQ in microalbuminuric and normoalbuminuric type 2 diabetic patients.
Jin et al. (2012)
4 more