› 5tvn

X-ray diffraction
2.9Å resolution

Crystal structure of the LSD-bound 5-HT2B receptor

Released:
DOI: 10.2210/pdb5tvn/pdb
PDB entry 5tvn coloured by chain, front view.
PDB entry 5tvn coloured by chain, side view.
PDB entry 5tvn coloured by chain, top view.
Source organisms:
Primary publication:
Crystal Structure of an LSD-Bound Human Serotonin Receptor.
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL
Cell 168 377-389.e12 (2017)
PMID: 28129538

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142091 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-hydroxytryptamine receptor 2B; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 402 amino acids
Theoretical weight: 45.23 KDa
Source organisms: Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: P41595 (Residues: 41-248, 308-308, 313-400; Coverage: 62%)
  • Canonical: P0ABE7 (Residues: 23-123, 125-128; Coverage: 99%)
Gene names: HTR2B, cybC
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand 7LD 1 x 7LD
Ligand CLR 1 x CLR
Ligand OLC 1 x OLC
Ligand PEG 1 x PEG
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2221
Unit cell:
a: 59.195Å b: 119.177Å c: 170.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.263
Expression system: Baculovirus expression vector pFastBac1-HM

Quick links

Citations

39 review citations

Molecular Dynamics Simulation for All.
Hollingsworth et al. (2018)
38 more

32 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
31 more