› 5twf

X-ray diffraction
3.14Å resolution

Regulation of protein interactions by MOB1 phosphorylation

Released:
DOI: 10.2210/pdb5twf/pdb
PDB entry 5twf coloured by chain, front view.
PDB entry 5twf coloured by chain, side view.
PDB entry 5twf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.
Xiong S, Couzens AL, Kean MJ, Mao DY, Guettler S, Kurinov I, Gingras AC, Sicheri F
Mol Cell Proteomics 16 1111-1125 (2017)
PMID: 28373297

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-190680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MOB kinase activator 1A Chains: A, B
Molecule details ›
Chains: A, B
Length: 216 amino acids
Theoretical weight: 25.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H8S9 (Residues: 1-216; Coverage: 100%)
Gene names: C2orf6, MOB1A, MOB4B, MOBK1B, MOBKL1B
Sequence domains: Mob1/phocein family
Structure domains: MOB kinase activator

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2221
Unit cell:
a: 86.132Å b: 86.16Å c: 138.081Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.263 0.291
Expression system: Escherichia coli

Quick links

Citations

10 review citations

AGC kinases, mechanisms of regulation ‎and innovative drug development.
Leroux et al. (2018)
9 more

1 mention without citation

Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.
Xiong et al. (2017)