› 5two

X-ray diffraction
1.93Å resolution

Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selectively PPAR gamma-modulating ligand VSP-51

Released:
DOI: 10.2210/pdb5two/pdb
PDB entry 5two coloured by chain, front view.
PDB entry 5two coloured by chain, side view.
PDB entry 5two coloured by chain, top view.
Source organisms:
Primary publication:
Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro.
Yi W, Shi J, Zhao G, Zhou XE, Suino-Powell K, Melcher K, Xu HE
Sci Rep 7 41487 (2017)
PMID: 28128331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153377 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 234-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.59 KDa
Source organism: unidentified
Expression system: Not provided
UniProt:
  • Canonical: Q9UBK2 (Residues: 138-152; Coverage: 2%)
Gene names: LEM6, PGC1, PGC1A, PPARGC1, PPARGC1A

Ligands and Environments

1 bound ligand:
Ligand 7MV 1 x 7MV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: C2221
Unit cell:
a: 56.893Å b: 88.504Å c: 122.163Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.236
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

The p38/MKP-1 signaling axis in oral cancer: Impact of tumor-associated macrophages.
Li et al. (2020)
1 more

3 mentions without citation

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.
Shang et al. (2018)
2 more