› 5u09

X-ray diffraction
2.6Å resolution

High-resolution crystal structure of the human CB1 cannabinoid receptor

Released:
DOI: 10.2210/pdb5u09/pdb
PDB entry 5u09 coloured by chain, front view.
PDB entry 5u09 coloured by chain, side view.
PDB entry 5u09 coloured by chain, top view.
Source organisms:
Primary publication:
High-resolution crystal structure of the human CB1 cannabinoid receptor.
Shao Z, Yin J, Chapman K, Grzemska M, Clark L, Wang J, Rosenbaum DM
Nature 540 602-606 (2016)
PMID: 27851727

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149292 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cannabinoid receptor 1; Starch synthase catalytic domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 508 amino acids
Theoretical weight: 57.4 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21554 (Residues: 90-301, 334-421; Coverage: 64%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
Gene names: CNR, CNR1, PAB2292
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand PEG 9 x PEG
Ligand SO4 4 x SO4
Ligand 7DY 1 x 7DY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 50.652Å b: 80.381Å c: 81.178Å
α: 90° β: 91.72° γ: 90°
R-values:
R R work R free
0.183 0.18 0.238
Expression system: Spodoptera frugiperda

Quick links

Citations

57 review citations

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.
Zou et al. (2018)
56 more

58 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
57 more