5u1d

Electron Microscopy
3.97Å resolution

Cryo-EM structure of the human TAP ATP-Binding Cassette Transporter

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-102931 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antigen peptide transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 748 amino acids
Theoretical weight: 81.03 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q03518 (Residues: 1-748; Coverage: 100%)
Gene names: ABCB2, PSF1, RING4, TAP1, Y3
Sequence domains:
Antigen peptide transporter 2 Chain: B
Molecule details ›
Chain: B
Length: 686 amino acids
Theoretical weight: 75.74 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q03519 (Residues: 1-686; Coverage: 100%)
Gene names: ABCB3, PSF2, RING11, TAP2, Y1
Sequence domains:
ICP47 protein Chain: X
Molecule details ›
Chain: X
Length: 88 amino acids
Theoretical weight: 9.85 KDa
Source organism: Human alphaherpesvirus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A140GKJ0 (Residues: 1-88; Coverage: 100%)
Gene name: US12
Sequence domains: Herpesvirus US12 family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.97Å
Relevant EMDB volumes: EMD-8482
Expression systems:
  • Komagataella pastoris
  • Escherichia coli BL21(DE3)