› 5u3w

X-ray diffraction
1.8Å resolution

Human PPARdelta ligand-binding domain in complexed with specific agonist 7

Released:
DOI: 10.2210/pdb5u3w/pdb
PDB entry 5u3w coloured by chain, front view.
PDB entry 5u3w coloured by chain, side view.
PDB entry 5u3w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.
Wu CC, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM
Proc Natl Acad Sci U S A 114 E2563-E2570 (2017)
PMID: 28320959

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 272 amino acids
Theoretical weight: 31.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 170-441; Coverage: 62%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

4 bound ligands:
Ligand B7G 2 x B7G
Ligand 7U1 2 x 7U1
Ligand PGO 4 x PGO
Ligand PEG 1 x PEG
1 modified residue:
Ligand CME 2 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 39.56Å b: 94.81Å c: 96.61Å
α: 90° β: 98.27° γ: 90°
R-values:
R R work R free
0.193 0.192 0.243
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor.
Liu et al. (2018)
2 more

1 mention without citation

Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.
Wu et al. (2017)