› 5u8r

X-ray diffraction
3Å resolution

Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor

Released:
DOI: 10.2210/pdb5u8r/pdb
PDB entry 5u8r coloured by chain, front view.
PDB entry 5u8r coloured by chain, side view.
PDB entry 5u8r coloured by chain, top view.
Source organisms:
Primary publication:
How ligand binds to the type 1 insulin-like growth factor receptor.
Xu Y, Kong GK, Menting JG, Margetts MB, Delaine CA, Jenkin LM, Kiselyov VV, De Meyts P, Forbes BE, Lawrence MC
Nat Commun 9 821 (2018)
PMID: 29483580

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230802 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Insulin-like growth factor 1 receptor alpha chain Chain: A
Molecule details ›
Chain: A
Length: 885 amino acids
Theoretical weight: 101.09 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08069 (Residues: 31-935; Coverage: 66%)
Gene name: IGF1R
Sequence domains:
Fv 24-60 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 126 amino acids
Theoretical weight: 13.95 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
Fv 24-60 light chain Chain: L
Molecule details ›
Chain: L
Length: 108 amino acids
Theoretical weight: 11.73 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand SO4 1 x SO4
Ligand MLT 2 x MLT
Ligand NAG 4 x NAG
Ligand IMD 1 x IMD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21212
Unit cell:
a: 95.03Å b: 201.73Å c: 117.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.256 0.285
Expression systems:
  • Cricetulus griseus
  • Spodoptera frugiperda

Quick links

Citations

14 review citations

Therapeutic Targeting of the IGF Axis.
Osher et al. (2019)
13 more

16 mentions without citation

Understanding insulin and its receptor from their three-dimensional structures.
Lawrence MC. (2021)
15 more