› 5uc3

X-ray diffraction
2.01Å resolution

Structure of the dominant negative mutant Glucocorticoid Receptor alpha (L733K/N734P) complexed with RU-486

Released:
DOI: 10.2210/pdb5uc3/pdb
PDB entry 5uc3 coloured by chain, front view.
PDB entry 5uc3 coloured by chain, side view.
PDB entry 5uc3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Min J, Cidlowski JA, Pedersen LC

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137452 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucocorticoid receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04150 (Residues: 522-777; Coverage: 33%)
Gene names: GRL, NR3C1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

4 bound ligands:
Ligand 486 2 x 486
Ligand MPD 3 x MPD
Ligand EDO 9 x EDO
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 136.749Å b: 88.32Å c: 64.672Å
α: 90° β: 110.84° γ: 90°
R-values:
R R work R free
0.18 0.178 0.212
Expression system: Escherichia coli

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