5udz

X-ray diffraction
2Å resolution

Human LIN28A in complex with let-7f-1 microRNA pre-element

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-190709 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Protein lin-28 homolog A Chains: A, B
Molecule details ›
Chains: A, B
Length: 148 amino acids
Theoretical weight: 16.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H9Z2 (Residues: 31-187; Coverage: 71%)
Gene names: CSDD1, LIN28, LIN28A, ZCCHC1
Sequence domains:
Structure domains:
let-7f-1 pre-element Chains: V, W
Molecule details ›
Chains: V, W
Length: 25 nucleotides
Theoretical weight: 8.07 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P41
Unit cell:
a: 76.429Å b: 76.429Å c: 105.615Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.164 0.2
Expression systems:
  • Escherichia coli
  • Not provided