› 5ui1

X-ray diffraction
1.96Å resolution

Crystal Structure of Human Protein Phosphatase 5C (PP5C) in complex with a triazole inhibitor

Released:
DOI: 10.2210/pdb5ui1/pdb
PDB entry 5ui1 coloured by chain, front view.
PDB entry 5ui1 coloured by chain, side view.
PDB entry 5ui1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chattopadhyay D, Swingle MR, Salter EA, Banerjee S, Honkanen RE

Function and Biology Details

Reaction catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156702 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein phosphatase 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 333 amino acids
Theoretical weight: 37.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53041 (Residues: 169-499; Coverage: 66%)
Gene names: PPP5, PPP5C
Sequence domains:
Structure domains: Purple Acid Phosphatase; chain A, domain 2

Ligands and Environments

2 bound ligands:
Ligand MN 8 x MN
Ligand 8D4 4 x 8D4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 40.805Å b: 80.708Å c: 91.384Å
α: 87.99° β: 87.1° γ: 86.33°
R-values:
R R work R free
0.213 0.211 0.246
Expression system: Escherichia coli

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