› 5unh

X-ray diffraction
2.9Å resolution

Synchrotron structure of human angiotensin II type 2 receptor in complex with compound 2 (N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide)

Released:
DOI: 10.2210/pdb5unh/pdb
PDB entry 5unh coloured by chain, front view.
PDB entry 5unh coloured by chain, side view.
PDB entry 5unh coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for selectivity and diversity in angiotensin II receptors.
Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V
Nature 544 327-332 (2017)
PMID: 28379944

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142102 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble cytochrome b562; Type-2 angiotensin II receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 411 amino acids
Theoretical weight: 46.51 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: P50052 (Residues: 35-335; Coverage: 83%)
Gene names: AGTR2, cybC
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 8EM 2 x 8EM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 78.42Å b: 68.2Å c: 89.06Å
α: 90° β: 104.32° γ: 90°
R-values:
R R work R free
0.218 0.216 0.259
Expression system: Spodoptera frugiperda

Quick links

Citations

35 review citations

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.
Forrester et al. (2018)
34 more

12 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
11 more