› 5uot

Electron Microscopy
4.6Å resolution

CryoEM structure of the helical assembly of full length MxB

Released:
DOI: 10.2210/pdb5uot/pdb
PDB entry 5uot coloured by chain, front view.
PDB entry 5uot coloured by chain, side view.
PDB entry 5uot coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.
Alvarez FJD, He S, Perilla JR, Jang S, Schulten K, Engelman AN, Scheres SHW, Zhang P
Sci Adv 3 e1701264 (2017)
PMID: 28929138
Related structures: EMD-8577

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 62-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149014 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced GTP-binding protein Mx2 Chains: 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z
Molecule details ›
Chains: 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z
Length: 619 amino acids
Theoretical weight: 70.98 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: P20592 (Residues: 93-711; Coverage: 87%)
Gene name: MX2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.6Å
Relevant EMDB volumes: EMD-8577
Expression system: Mammalia

Quick links

Citations

13 review citations

Structural Insights into the Mechanism of Dynamin Superfamily Proteins.
Jimah et al. (2019)
12 more

3 mentions without citation

Deciphering the three-domain architecture in schlafens and the structures and roles of human schlafen12 and serpinB12 in transcriptional regulation.
Chen et al. (2019)
2 more