› 5up7

X-ray diffraction
1.79Å resolution

Crystal Structure of the Ni-bound Human Heavy-Chain Ferritin 122H-delta C-star variant

Released:
DOI: 10.2210/pdb5up7/pdb
PDB entry 5up7 coloured by chain, front view.
PDB entry 5up7 coloured by chain, side view.
PDB entry 5up7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Synthetic Modularity of Protein-Metal-Organic Frameworks.
Bailey JB, Zhang L, Chiong JA, Ahn S, Tezcan FA
J Am Chem Soc 139 8160-8166 (2017)
PMID: 28590729

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 100%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

4 bound ligands:
Ligand NI 5 x NI
Ligand CA 2 x CA
Ligand CL 1 x CL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: F432
Unit cell:
a: 180.15Å b: 180.15Å c: 180.15Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.159 not available
Expression system: Escherichia coli

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Citations

9 review citations

Self-assembly as a key player for materials nanoarchitectonics.
Ariga et al. (2019)
8 more