› 5ura

X-ray diffraction
1.85Å resolution

Enantiomer-Specific Binding of the Potent Antinociceptive Agent SBFI-26 to Anandamide transporters FABP7

Released:
DOI: 10.2210/pdb5ura/pdb
PDB entry 5ura coloured by chain, front view.
PDB entry 5ura coloured by chain, side view.
PDB entry 5ura coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites.
Hsu HC, Tong S, Zhou Y, Elmes MW, Yan S, Kaczocha M, Deutsch DG, Rizzo RC, Ojima I, Li H
Biochemistry 56 3454-3462 (2017)
PMID: 28632393

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127524 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, brain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 135 amino acids
Theoretical weight: 15.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15540 (Residues: 1-132; Coverage: 100%)
Gene names: BLBP, FABP7, FABPB, MRG
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:
Ligand 8KS 4 x 8KS
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 53.84Å b: 73.33Å c: 70.53Å
α: 90° β: 92.98° γ: 90°
R-values:
R R work R free
0.181 0.18 0.206
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years.
Maccarrone et al. (2023)
1 more

4 mentions without citation

Impact of Intracellular Lipid Binding Proteins on Endogenous and Xenobiotic Ligand Metabolism and Disposition.
Yabut et al. (2023)
3 more