› 5urv

X-ray diffraction
2.2Å resolution

Crystal structure of Frizzled 7 CRD in complex with C24 fatty acid

Released:
DOI: 10.2210/pdb5urv/pdb
PDB entry 5urv coloured by chain, front view.
PDB entry 5urv coloured by chain, side view.
PDB entry 5urv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.
Nile AH, Mukund S, Stanger K, Wang W, Hannoush RN
Proc Natl Acad Sci U S A 114 4147-4152 (2017)
PMID: 28377511

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130832 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Frizzled-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 148 amino acids
Theoretical weight: 16.47 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75084 (Residues: 30-168; Coverage: 25%)
Gene name: FZD7
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain

Ligands and Environments

4 bound ligands:
Ligand NER 1 x NER
Ligand NAG 2 x NAG
Ligand SO4 8 x SO4
Ligand 1PG 3 x 1PG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21212
Unit cell:
a: 97.56Å b: 104.902Å c: 41.351Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.163 0.21
Expression system: Trichoplusia ni

Quick links

Citations

16 review citations

WNT signalling in prostate cancer.
Murillo-Garzón et al. (2017)
15 more

6 mentions without citation

Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B.
Chen et al. (2019)
5 more