5uwm

X-ray diffraction
1.62Å resolution

Matrix metalloproteinase-13 complexed with selective inhibitor compound (R)-17a

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155287 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Collagenase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 172 amino acids
Theoretical weight: 19.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45452 (Residues: 104-274; Coverage: 38%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)
Collagenase 3 Chains: C, D
Molecule details ›
Chains: C, D
Length: 5 amino acids
Theoretical weight: 543 Da
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45452 (Residues: 148-152; Coverage: 1%)
Gene name: MMP13

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: R3
Unit cell:
a: 140.073Å b: 140.073Å c: 46.86Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.131 0.129 0.178
Expression system: Escherichia coli BL21(DE3)