› 5uyx

X-ray diffraction
3.5Å resolution

Structure of Human T-complex protein 1 subunit epsilon (CCT5)

Released:
DOI: 10.2210/pdb5uyx/pdb
PDB entry 5uyx coloured by chain, front view.
PDB entry 5uyx coloured by chain, side view.
PDB entry 5uyx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.
Pereira JH, McAndrew RP, Sergeeva OA, Ralston CY, King JA, Adams PD
Sci Rep 7 3673 (2017)
PMID: 28623285

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-complex protein 1 subunit epsilon Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 541 amino acids
Theoretical weight: 59.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48643 (Residues: 1-541; Coverage: 100%)
Gene names: CCT5, CCTE, KIAA0098
Sequence domains: TCP-1/cpn60 chaperonin family

Ligands and Environments

1 bound ligand:
Ligand ADP 4 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P4212
Unit cell:
a: 204.71Å b: 204.71Å c: 162.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.271 0.269 0.318
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Mitochondrial stress management: a dynamic journey.
Valera-Alberni et al. (2018)
4 more

2 mentions without citation

Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.
Pereira et al. (2017)
1 more