› 5uzb

Electron Microscopy
7Å resolution

Cryo-EM structure of the MAL TIR domain filament

Released:
DOI: 10.2210/pdb5uzb/pdb
PDB entry 5uzb coloured by chain, front view.
PDB entry 5uzb coloured by chain, side view.
PDB entry 5uzb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.
Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carroll A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B
Nat Struct Mol Biol 24 743-751 (2017)
PMID: 28759049
Related structures: EMD-8625

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetradecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157719 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll/interleukin-1 receptor domain-containing adapter protein Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N
Length: 177 amino acids
Theoretical weight: 19.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P58753 (Residues: 79-221; Coverage: 65%)
Gene names: MAL, TIRAP
Sequence domains: TIR domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7Å
Relevant EMDB volumes: EMD-8625
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Structural and functional understanding of the toll-like receptors.
Asami et al. (2021)
16 more

7 mentions without citation

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.
Ve et al. (2017)
6 more