› 5v18

X-ray diffraction
2.15Å resolution

Function and Biology Details

Reaction catalysed: 
Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190450 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Egl nine homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 239 amino acids
Theoretical weight: 26.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZT9 (Residues: 181-416; Coverage: 55%)
Gene names: C1orf12, EGLN1, PNAS-118, PNAS-137
Sequence domains: 2OG-Fe(II) oxygenase superfamily
Structure domains: q2cbj1_9rhob like domain

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand 8UY 1 x 8UY
Ligand FE2 1 x FE2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P41
Unit cell:
a: 72.528Å b: 72.528Å c: 45.642Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.235
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The pyridazine heterocycle in molecular recognition and drug discovery.
Meanwell NA. (2023)
5 other articles

2 mentions without citation

Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat.
Figg et al. (2021)
1 more