› 5v4e

X-ray diffraction
3.22Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (6 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 226 amino acids
Theoretical weight: 25.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 104-328; Coverage: 56%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN, NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN, NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN, NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN, NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN, NAG, BMA, FUC
Carbohydrate polymer
3 bound ligands:
Ligand K 2 x K
Ligand MAN 2 x MAN
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P21
Unit cell:
a: 93.615Å b: 141.02Å c: 98.866Å
α: 90° β: 117.33° γ: 90°
R-values:
R R work R free
0.238 0.236 0.281
Expression system: Homo sapiens

Quick links

Citations

32 review citations

Context-dependent roles of complement in cancer.
Roumenina et al. (2019)
31 more

3 mentions without citation

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.
Lee et al. (2017)
2 more