5v52

X-ray diffraction
3.1Å resolution

Structure of TIGIT bound to nectin-2 (CD112)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-175399 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
T-cell immunoreceptor with Ig and ITIM domains Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 11.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q495A1 (Residues: 22-128; Coverage: 48%)
Gene names: TIGIT, VSIG9, VSTM3
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Nectin-2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 140 amino acids
Theoretical weight: 15.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92692 (Residues: 32-158; Coverage: 25%)
Gene names: HVEB, NECTIN2, PRR2, PVRL2
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 68.5Å b: 68.5Å c: 253.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 0.236
Expression systems:
  • Escherichia coli
  • Homo sapiens