› 5vax

X-ray diffraction
2Å resolution

Bcl-2 complex with Beclin 1 BH3 domain

Released:
DOI: 10.2210/pdb5vax/pdb
PDB entry 5vax coloured by chain, front view.
PDB entry 5vax coloured by chain, side view.
PDB entry 5vax coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lee EF, Smith BJ, Yao S, Fairlie WD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145308 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator Bcl-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 168 amino acids
Theoretical weight: 19.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P10415 (Residues: 1-207; Coverage: 70%)
Gene name: BCL2
Sequence domains:
Beclin-1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 26 amino acids
Theoretical weight: 2.93 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q14457 (Residues: 105-130; Coverage: 6%)
Gene names: BECN1, GT197
Sequence domains: Beclin-1 BH3 domain, Bcl-2-interacting

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TPO 4 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 66.474Å b: 87.174Å c: 126.631Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.243
Expression systems:
  • Escherichia coli K-12
  • Not provided

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