› 5vdi

X-ray diffraction
3.1Å resolution

Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607, Glycine, and Ivermectin

Released:
DOI: 10.2210/pdb5vdi/pdb
PDB entry 5vdi coloured by chain, front view.
PDB entry 5vdi coloured by chain, side view.
PDB entry 5vdi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structures of Human GlyRα3 Bound to Ivermectin.
Huang X, Chen H, Shaffer PL
Structure 25 945-950.e2 (2017)
PMID: 28479061

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycine receptor subunit alpha-3 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 362 amino acids
Theoretical weight: 41.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75311 (Residues: 34-342, 419-460; Coverage: 81%)
Gene name: GLRA3
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand 7C6 5 x 7C6
Ligand GLY 5 x GLY
Ligand IVM 5 x IVM
Ligand ZN 5 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 136.006Å b: 136Å c: 191.635Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.232 0.256
Expression system: Spodoptera frugiperda

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Citations

7 review citations

Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.
Chen et al. (2018)
6 more

6 mentions without citation

Pose Classification Using Three-Dimensional Atomic Structure-Based Neural Networks Applied to Ion Channel-Ligand Docking.
Shim et al. (2022)
5 more