› 5ved

X-ray diffraction
2.3Å resolution

PAK4 kinase domain in complex with Staurosporine

Released:
DOI: 10.2210/pdb5ved/pdb
PDB entry 5ved coloured by chain, front view.
PDB entry 5ved coloured by chain, side view.
PDB entry 5ved coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PAK4 crystal structures suggest unusual kinase conformational movements.
Zhang EY, Ha BH, Boggon TJ
Biochim Biophys Acta Proteins Proteom 1866 356-365 (2018)
PMID: 28993291

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 319 amino acids
Theoretical weight: 36.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O96013 (Residues: 286-591; Coverage: 52%)
Gene names: KIAA1142, PAK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand STU 1 x STU
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P41212
Unit cell:
a: 62.716Å b: 62.716Å c: 177.197Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.277
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Progress in the therapeutic inhibition of Cdc42 signalling.
Murphy et al. (2021)
5 other articles

1 mention without citation

PAK4 crystal structures suggest unusual kinase conformational movements.
Zhang et al. (2018)