› 5vfw

Solution NMR

An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease

Released:
DOI: 10.2210/pdb5vfw/pdb
PDB entry 5vfw coloured by chain, ensemble of 20 models, front view.
PDB entry 5vfw coloured by chain, ensemble of 20 models, side view.
PDB entry 5vfw coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.
Cobos Caceres C, Bansal PS, Navarro S, Wilson D, Don L, Giacomin P, Loukas A, Daly NL
J Biol Chem 292 10288-10294 (2017)
PMID: 28473469

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin Ac2-26 Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 3.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04083 (Residues: 2-26; Coverage: 7%)
Gene names: ANX1, ANXA1, LPC1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 53%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

11 review citations

Peptides as Therapeutic Agents for Inflammatory-Related Diseases.
La Manna et al. (2018)
10 more

1 mention without citation

An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.
Cobos Caceres et al. (2017)