5viy

Electron Microscopy
6.2Å resolution

BG505 SOSIP.664 in complex with broadly neutralizing antibodies BG1 and 8ANC195

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
PDBe Complex ID:
PDB-CPX-134649 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (14 distinct):
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
Envelope glycoprotein gp160 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 481 amino acids
Theoretical weight: 54.06 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-508; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Immunoglobulin kappa constant Chains: G, I
Molecule details ›
Chains: G, I
Length: 214 amino acids
Theoretical weight: 23.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Ig-like domain-containing protein Chains: H, J
Molecule details ›
Chains: H, J
Length: 233 amino acids
Theoretical weight: 24.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 22-72, 73-117, 118-236; Coverage: 48%)
Sequence domains:
Ig-like domain-containing protein Chains: K, M, O
Molecule details ›
Chains: K, M, O
Length: 233 amino acids
Theoretical weight: 24.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 20-46, 47-90, 91-119, 120-125, 126-237; Coverage: 48%)
Sequence domains:
Ig-like domain-containing protein Chains: L, N, P
Molecule details ›
Chains: L, N, P
Length: 215 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TCD0 (Residues: 21-239; Coverage: 98%)
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.2Å
Relevant EMDB volumes: EMD-8693
Expression system: Homo sapiens