› 5vkc

X-ray diffraction
2.31Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170545 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Induced myeloid leukemia cell differentiation protein Mcl-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 157 amino acids
Theoretical weight: 17.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07820 (Residues: 174-326; Coverage: 44%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

2 bound ligands:
Ligand 9EA 2 x 9EA
Ligand ZN 10 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P32
Unit cell:
a: 63.92Å b: 63.92Å c: 91.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.201 0.222
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies.
Pistritto et al. (2016)
24 more

1 mention without citation

Targeting MCL-1 in cancer: current status and perspectives.
Wang et al. (2021)