› 5vkj

X-ray diffraction
2.12Å resolution

Crystal structure of human CD22 Ig domains 1-3

Released:
DOI: 10.2210/pdb5vkj/pdb
PDB entry 5vkj coloured by chain, front view.
PDB entry 5vkj coloured by chain, side view.
PDB entry 5vkj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of human CD22 function and therapeutic targeting.
Ereño-Orbea J, Sicard T, Cui H, Mazhab-Jafari MT, Benlekbir S, Guarné A, Rubinstein JL, Julien JP
Nat Commun 8 764 (2017)
PMID: 28970495

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148914 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
B-cell receptor CD22 Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 36.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20273 (Residues: 20-330; Coverage: 38%)
Gene names: CD22, SIGLEC2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2
Unit cell:
a: 126.807Å b: 56.569Å c: 49.434Å
α: 90° β: 110.7° γ: 90°
R-values:
R R work R free
0.204 0.202 0.232
Expression system: Homo sapiens

Quick links

Citations

31 review citations

Glycosylation in health and disease.
Reily et al. (2019)
30 more

8 mentions without citation

Current Status on Therapeutic Molecules Targeting Siglec Receptors.
Lenza et al. (2020)
7 more