› 5vlo

X-ray diffraction
2.05Å resolution

The structure of human CamKII with bound inhibitor

Released:
DOI: 10.2210/pdb5vlo/pdb
PDB entry 5vlo coloured by chain, front view.
PDB entry 5vlo coloured by chain, side view.
PDB entry 5vlo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Somoza JR, Villasenor AG

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type II subunit delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 34.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13557 (Residues: 3-301; Coverage: 60%)
Gene names: CAMK2D, CAMKD
Sequence domains: Protein kinase domain
Structure domains: Phosphorylase Kinase; domain 1

Ligands and Environments

2 bound ligands:
Ligand 9EJ 2 x 9EJ
Ligand DTT 2 x DTT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 54.473Å b: 67.546Å c: 85.45Å
α: 90° β: 94.111° γ: 90°
R-values:
R R work R free
0.184 0.183 0.226
Expression system: Escherichia coli

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