Function and Biology Details
Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphomonoester
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Protein argonaute-3 and RNA (preferred)
PDBe Complex ID:
PDB-CPX-219663 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct RNA molecules
2 distinct RNA molecules
Macromolecules (3 distinct):
Protein argonaute-3
Molecule details ›
Chains: A, C
Length: 862 amino acids
Theoretical weight: 97.65 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
Sequence domains:
Length: 862 amino acids
Theoretical weight: 97.65 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
- Canonical:
Q9H9G7 (Residues: 1-860; Coverage: 100%)
Sequence domains:
- N-terminal domain of argonaute
- Argonaute linker 1 domain
- PAZ domain
- Argonaute linker 2 domain
- Mid domain of argonaute
- Piwi domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 24-ID-E
Spacegroup:
P43
Expression system: Insect cell expression vector pTIE1
