› 5vmd

X-ray diffraction
2.2Å resolution

Crystal structure of UBR-box from UBR6 in a domain-swapping conformation

Released:
DOI: 10.2210/pdb5vmd/pdb
PDB entry 5vmd coloured by chain, front view.
PDB entry 5vmd coloured by chain, side view.
PDB entry 5vmd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the UBR-box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding.
Muñoz-Escobar J, Kozlov G, Gehring K
Protein Sci 26 2092-2097 (2017)
PMID: 28691247

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183252 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
F-box only protein 11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 77 amino acids
Theoretical weight: 8.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q86XK2 (Residues: 833-904; Coverage: 8%)
Gene names: FBX11, FBXO11, PRMT9, UG063H01, VIT1
Sequence domains: Putative zinc finger in N-recognin (UBR box)

Ligands and Environments

2 bound ligands:
Ligand ZN 14 x ZN
Ligand EDO 9 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: P212121
Unit cell:
a: 67.57Å b: 69.2Å c: 82.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.247
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

It's not just a phase; ubiquitination in cytosolic protein quality control.
Baker et al. (2021)
5 other articles

2 mentions without citation

De Novo Variants in the F-Box Protein FBXO11 in 20 Individuals with a Variable Neurodevelopmental Disorder.
Gregor et al. (2018)
1 more