› 5vos

Electron crystallography
1.42Å resolution

VGSNKGAIIGL from Amyloid Beta determined by MicroED

Released:
DOI: 10.2210/pdb5vos/pdb
PDB entry 5vos coloured by chain, front view.
PDB entry 5vos coloured by chain, side view.
PDB entry 5vos coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS
J Biol Chem 293 2888-2902 (2018)
PMID: 29282295
Related structures: EMD-8720

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(40) Chain: A
Molecule details ›
Chain: A
Length: 11 amino acids
Theoretical weight: 1.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 695-705; Coverage: 2%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 1.42Å
Relevant EMDB volumes: EMD-8720
Expression system: Not provided

Quick links

Citations

12 review citations

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.
Nguyen et al. (2021)
11 more

4 mentions without citation

Electron Diffraction of 3D Molecular Crystals.
Saha et al. (2022)
3 more