› 5vqp

X-ray diffraction
2.9Å resolution

Crystal structure of human pro-TGF-beta1

Released:
DOI: 10.2210/pdb5vqp/pdb
PDB entry 5vqp coloured by chain, front view.
PDB entry 5vqp coloured by chain, side view.
PDB entry 5vqp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Prodomain-growth factor swapping in the structure of pro-TGF-β1.
Zhao B, Xu S, Dong X, Lu C, Springer TA
J Biol Chem 293 1579-1589 (2018)
PMID: 29109152

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134058 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Transforming growth factor beta-1 proprotein Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 41.49 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01137 (Residues: 30-390; Coverage: 100%)
Gene names: TGFB, TGFB1
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P622
Unit cell:
a: 104.39Å b: 104.39Å c: 141.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.252 0.293
Expression system: Cricetulus griseus

Quick links

Citations

7 review citations

Specification of BMP Signaling.
Nickel et al. (2019)
6 more

19 mentions without citation

Prodomain-growth factor swapping in the structure of pro-TGF-β1.
Zhao et al. (2018)
18 more