› 5vtb

X-ray diffraction
2.4Å resolution

Crystal structure of RBBP4 bound to BCL11a peptide

Released:
DOI: 10.2210/pdb5vtb/pdb
PDB entry 5vtb coloured by chain, front view.
PDB entry 5vtb coloured by chain, side view.
PDB entry 5vtb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.
Moody RR, Lo MC, Meagher JL, Lin CC, Stevers NO, Tinsley SL, Jung I, Matvekas A, Stuckey JA, Sun D
J Biol Chem 293 2125-2136 (2018)
PMID: 29263092

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170750 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone-binding protein RBBP4 Chain: A
Molecule details ›
Chain: A
Length: 432 amino acids
Theoretical weight: 48.46 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q09028 (Residues: 1-425; Coverage: 100%)
Gene names: RBAP48, RBBP4
Sequence domains:
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
B-cell lymphoma/leukemia 11A Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9H165 (Residues: 2-16; Coverage: 2%)
Gene names: BCL11A, CTIP1, EVI9, KIAA1809, ZNF856

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 51.301Å b: 85.264Å c: 87.968Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.244
Expression systems:
  • unidentified baculovirus
  • Not provided

Quick links

Citations

8 review citations

PRC2 is high maintenance.
Yu et al. (2019)
7 more

3 mentions without citation

Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.
Moody et al. (2018)
2 more