› 5vx2

X-ray diffraction
1.85Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128971 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1; Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Chains: A, C
Molecule details ›
Chains: A, C
Length: 162 amino acids
Theoretical weight: 18.23 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P97287 (Residues: 152-221; Coverage: 21%)
  • Canonical: Q07820 (Residues: 241-327; Coverage: 25%)
Gene names: BCL2L3, MCL1, Mcl1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Bcl-2-like protein 11 Chains: B, D
Molecule details ›
Chains: B, D
Length: 26 amino acids
Theoretical weight: 3.24 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43521 (Residues: 141-166; Coverage: 13%)
Gene names: BCL2L11, BIM
Sequence domains: Bcl-x interacting, BH3 domain

Ligands and Environments

1 bound ligand:
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 42.031Å b: 66.157Å c: 76.673Å
α: 90° β: 105.02° γ: 90°
R-values:
R R work R free
0.172 0.169 0.21
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

12 review citations

Mitochondria as multifaceted regulators of cell death.
Bock et al. (2020)
11 more