› 5vxz

X-ray diffraction
2.3Å resolution

High-affinity AXL decoy receptor

Released:
DOI: 10.2210/pdb5vxz/pdb
PDB entry 5vxz coloured by chain, front view.
PDB entry 5vxz coloured by chain, side view.
PDB entry 5vxz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.
Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ
J Clin Invest 127 183-198 (2017)
PMID: 27893463

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151755 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Growth arrest-specific protein 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 395 amino acids
Theoretical weight: 43.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14393 (Residues: 281-675; Coverage: 61%)
Gene names: AXLLG, GAS6
Sequence domains:
Structure domains: Jelly Rolls
Tyrosine-protein kinase receptor UFO Chains: C, D
Molecule details ›
Chains: C, D
Length: 102 amino acids
Theoretical weight: 11.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30530 (Residues: 34-135; Coverage: 12%)
Gene names: AXL, UFO
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand CA 2 x CA
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 77.22Å b: 80.47Å c: 249.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.247
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications.
Zhu et al. (2019)
20 more

2 mentions without citation

Prediction analysis of porcine AXL protein as a potential receptor for SARS-CoV-2.
Zeng et al. (2022)
1 more